Granzyme-mediated programmed cell death signaling pathway

Across TCGA cell cohorts, RNA activity of the Granzyme-mediated programmed cell death signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOC, H3-3A, and PTMA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granzyme-mediated programmed cell death signaling pathway activity versus RHOC in BLOOD_Lymphoma (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RHOC →	-2.930	-0.152	.004	.003	3	8
LUNG_SCLC	H3-3A →	+1.005	+0.211	.003	.005	3	8
KIDNEY	PTMA →	+0.831	+0.293	.009	.008	3	7
LUNG_SCLC	ZNF48 →	+1.030	+0.260	<.001	<.001	3	6
STOMACH	SRRT →	+0.815	+0.396	.005	.006	2	7
STOMACH	NYNRIN →	+2.055	+0.328	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140507 vs RHOC — BLOOD_Lymphoma

Explore this scatter interactively →