Response to Gram-positive bacterium

Across TCGA patient cohorts, RNA activity of the Response to Gram-positive bacterium pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A1, BCKDK, and ABHD11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to Gram-positive bacterium activity versus SLC6A1 in CCRCC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC6A1 →	-0.619	-0.685	.002	<.001	3	4
GBM	BCKDK →	+0.365	+0.760	<.001	.002	3	4
LSCC	ABHD11 →	+0.574	+0.201	<.001	<.001	3	4
GBM	VEGFA →	+1.090	+0.593	.003	.005	2	5
COAD	FOXH1 →	+0.312	+0.528	.002	.005	3	3
LUAD	DTWD1 →	-0.212	-0.229	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140459 vs SLC6A1 — CCRCC

Explore this scatter interactively →