Response to Gram-positive bacterium

Across TCGA cell cohorts, RNA activity of the Response to Gram-positive bacterium pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLE3, DHX34, and ERF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLE3 grouped by Response to Gram-positive bacterium-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TLE3 →	-1.342	-1.367	.002	.002	3	4
SOFT_TISSUE	DHX34 →	-0.558	-1.046	.009	<.001	3	4
SKIN	ERF →	-0.432	-1.078	.009	.001	3	4
SKIN	DAPK1 →	+1.879	+1.236	.001	<.001	3	4
OVARY	ZNF365 →	-0.785	-1.063	<.001	.004	3	4
BLOOD_Leukemia	KHNYN →	-0.674	-1.056	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLE3 by Response to Gram-positive bacterium activity — STOMACH

Explore this box plot interactively →