Response to Gram-positive bacterium

Across TCGA cell cohorts, RNA activity of the Response to Gram-positive bacterium pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP6R1, MYH14, and RBM47, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to Gram-positive bacterium activity versus PPP6R1 in OVARY (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PPP6R1 →	+1.079	+1.923	<.001	<.001	3	2
OVARY	MYH14 →	+3.249	+1.963	.001	<.001	3	2
LUNG_SCLC	RBM47 →	+2.862	+0.971	.001	.003	3	2
OVARY	DNAAF2 →	-0.779	-2.149	.008	<.001	3	2
OVARY	TAPBP →	+0.615	+2.026	.005	<.001	3	2
LUNG_SCLC	SLPI →	+2.905	+1.158	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140459 vs PPP6R1 — OVARY

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