Signaling receptor ligand precursor processing

Across TCGA cell cohorts, RNA activity of the Signaling receptor ligand precursor processing pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADRB2, NDUFS5, and INTS7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADRB2 grouped by Signaling receptor ligand precursor processing-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ADRB2 →	+2.120	+1.922	.002	.003	3	4
BONE	NDUFS5 →	-1.008	-1.891	<.001	<.001	3	4
BLOOD_Leukemia	INTS7 →	-0.658	-1.130	.003	.002	3	4
BLOOD_Leukemia	SSBP2 →	-1.702	-0.968	.002	.001	3	4
BLOOD_Leukemia	SLC18B1 →	-1.898	-1.056	.002	.003	3	4
KIDNEY	ACTR1B →	+0.682	+0.923	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADRB2 by Signaling receptor ligand precursor processing activity — URINARY_TRACT

Explore this box plot interactively →