Lipid export from cell

Across TCGA cell cohorts, RNA activity of the Lipid export from cell pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH3B1, CTSD, and PPP1R18, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALDH3B1 grouped by Lipid export from cell-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ALDH3B1 →	-2.191	-1.486	.001	<.001	3	7
BONE	CTSD →	-1.320	-0.367	.005	.007	3	5
LIVER	PPP1R18 →	-2.916	-1.774	.002	.006	3	5
BONE	FOSL2 →	-2.762	-0.370	.009	.006	3	5
LIVER	GLIS3 →	-2.058	-1.868	<.001	<.001	3	5
CNS	IFI27L2 →	-1.162	-0.883	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALDH3B1 by Lipid export from cell activity — LIVER

Explore this box plot interactively →