Regulation protein catabolic process at synapse

Across TCGA patient cohorts, RNA activity of the Regulation protein catabolic process at synapse pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STUB1_S19, LGALS1, and TRIP6_S135, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation protein catabolic process at synapse activity versus STUB1_S19 in COAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	STUB1_S19 →	+0.579	+0.048	<.001	<.001	3	7
LSCC	LGALS1 →	-0.398	-0.050	<.001	<.001	3	6
PDAC	TRIP6_S135 →	-1.241	-0.051	<.001	<.001	3	6
OV	SGCD →	-0.766	-0.041	<.001	.003	3	6
PDAC	CNN1 →	-0.529	-0.027	<.001	.006	3	6
LUAD	TBL3 →	+0.242	+0.052	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140250 vs STUB1_S19 — COAD

Explore this scatter interactively →