Regulation of translation at synapse

Across TCGA patient cohorts, RNA activity of the Regulation of translation at synapse pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDC42BPB, EIF4E, and FASN_T2204, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation at synapse activity versus CDC42BPB in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDC42BPB →	+0.281	+0.044	.002	<.001	2	6
UCEC	EIF4E →	+0.188	+0.059	.001	<.001	3	5
PDAC	FASN_T2204 →	+0.608	+0.048	<.001	<.001	3	5
LSCC	PRRC2B →	+0.185	+0.027	.001	.004	3	5
LUAD	DOCK10 →	-0.338	-0.050	<.001	<.001	3	5
LUAD	LSP1 →	-0.332	-0.035	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140243 vs CDC42BPB — BRCA

Explore this scatter interactively →