Regulation of long-chain fatty acid import into cell

Across TCGA cell cohorts, RNA activity of the Regulation of long-chain fatty acid import into cell pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOMM7, PMPCB, and ALKBH4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-chain fatty acid import into cell activity versus TOMM7 in LARGE_INTESTINE (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TOMM7 →	-0.743	-0.248	<.001	.001	3	4
URINARY_TRACT	PMPCB →	+1.070	+0.493	.001	.003	3	4
BLOOD_Lymphoma	ALKBH4 →	+0.748	+0.350	<.001	<.001	3	4
KIDNEY	AKT1S1 →	-0.730	-0.410	.008	.002	3	4
LIVER	KDM6A →	-1.380	-0.497	.003	<.001	3	4
OESOPHAGUS	CROT →	+1.342	+0.312	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140212 vs TOMM7 — LARGE_INTESTINE

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