Positive regulation of lymphocyte chemotaxis

Across TCGA patient cohorts, RNA activity of the Positive regulation of lymphocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKP4-AS1, GPR21, and PAK5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lymphocyte chemotaxis activity versus PKP4-AS1 in HNSC (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PKP4-AS1 →	-0.415	-0.240	<.001	<.001	3	4
GBM	GPR21 →	-0.331	-0.305	<.001	.003	3	4
LUAD	PAK5 →	-0.124	-0.344	.006	.003	3	3
LUAD	RN7SKP128 →	-0.187	-0.374	.001	<.001	3	3
COAD	APCDD1 →	+1.325	+0.290	.004	<.001	3	3
HNSC	HPD →	-0.576	-0.271	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140131 vs PKP4-AS1 — HNSC

Explore this scatter interactively →