Extracellular vesicle biogenesis

Across TCGA patient cohorts, RNA activity of the Extracellular vesicle biogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS8, BGN, and TFRC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular vesicle biogenesis activity versus RPS8 in BRCA (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS8 →	-0.409	-0.060	<.001	<.001	3	7
OV	BGN →	+0.792	+0.060	<.001	<.001	3	7
LUAD	TFRC →	-0.335	-0.033	.009	<.001	3	7
OV	RPL21 →	-0.331	-0.048	<.001	<.001	3	6
BRCA	RPS3A →	-0.236	-0.052	<.001	<.001	3	6
OV	PLAC9 →	+0.919	+0.051	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140112 vs RPS8 — BRCA

Explore this scatter interactively →