Extracellular vesicle biogenesis

Across TCGA patient cohorts, RNA activity of the Extracellular vesicle biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM1P27, RPL7P52, and ZNF286B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular vesicle biogenesis activity versus NPM1P27 in LSCC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NPM1P27 →	-0.260	-0.134	.002	.002	3	5
BRCA	RPL7P52 →	-0.602	-0.191	<.001	<.001	3	5
BRCA	ZNF286B →	-0.630	-0.197	<.001	.001	3	5
OV	C16orf54 →	+0.409	+0.158	.008	.005	3	4
OV	RPS15AP1 →	-1.101	-0.150	.002	.008	3	4
UCEC	TPR →	-0.562	-0.195	.004	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140112 vs NPM1P27 — LSCC

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