Extracellular vesicle biogenesis

Across TCGA cell cohorts, RNA activity of the Extracellular vesicle biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB27A, PRXL2B, and PRDM8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular vesicle biogenesis activity versus RAB27A in BLOOD_Leukemia (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAB27A →	+2.055	+0.293	<.001	<.001	3	6
STOMACH	PRXL2B →	+1.575	+1.108	.003	.002	3	5
BLOOD_Lymphoma	PRDM8 →	+2.153	+0.173	.001	<.001	3	5
OVARY	ANTXR2 →	+1.441	+0.879	.009	<.001	3	5
BREAST	CENPM →	+1.106	+0.731	<.001	.003	3	4
BREAST	C18orf21 →	+0.873	+0.550	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140112 vs RAB27A — BLOOD_Leukemia

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