Neuron projection arborization

Across TCGA patient cohorts, RNA activity of the Neuron projection arborization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21_S89, ADIRF, and MACROH2A1_T129, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection arborization activity versus DDX21_S89 in LUAD (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DDX21_S89 →	-0.980	-0.053	<.001	<.001	3	6
BRCA	ADIRF →	+0.986	+0.021	<.001	.009	3	6
LUAD	MACROH2A1_T129 →	-0.377	-0.062	.001	<.001	3	6
LUAD	HIP1 →	+0.286	+0.037	<.001	<.001	3	6
BRCA	NOP2 →	-0.465	-0.024	.006	.003	3	6
LSCC	DDX52 →	-0.298	-0.060	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140058 vs DDX21_S89 — LUAD

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