Neuron projection arborization

Across TCGA patient cohorts, RNA activity of the Neuron projection arborization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACF1, COLEC12, and EHD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection arborization activity versus MACF1 in HNSC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MACF1 →	+0.644	+0.400	.002	.005	3	5
LSCC	COLEC12 →	+0.756	+0.279	<.001	<.001	3	5
GBM	EHD3 →	+0.620	+0.252	<.001	<.001	3	4
CCRCC	CBFA2T3 →	-0.334	-0.998	<.001	<.001	3	4
CCRCC	MAP3K19 →	-0.093	-0.682	.008	.003	3	4
LSCC	SYNC →	+0.397	+0.281	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140058 vs MACF1 — HNSC

Explore this scatter interactively →