Neuron projection arborization

Across TCGA patient cohorts, RNA activity of the Neuron projection arborization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRRK2, MTARC2, and STXBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection arborization activity versus LRRK2 in COAD (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LRRK2 →	+1.341	+0.787	.006	<.001	2	5
GBM	MTARC2 →	+0.666	+0.292	<.001	<.001	3	4
GBM	STXBP1 →	+0.630	+0.255	<.001	<.001	3	4
OV	C1orf174_S148 →	-1.244	-0.901	<.001	<.001	3	3
GBM	CAMSAP3_S334 →	+0.646	+0.252	<.001	.001	3	3
LUAD	CMTM4_S194 →	+1.023	+0.250	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140058 vs LRRK2 — COAD

Explore this scatter interactively →