Neuron projection arborization

Across TCGA cell cohorts, RNA activity of the Neuron projection arborization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROCK1, NRP1, and TUBA1A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection arborization activity versus ROCK1 in STOMACH (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ROCK1 →	+1.262	+0.144	.001	.001	3	10
LUNG_NSCLC_LUSC	NRP1 →	+4.258	+0.280	<.001	.003	3	9
BREAST	TUBA1A →	+2.431	+0.144	<.001	<.001	3	9
STOMACH	STX2 →	+1.167	+0.159	.001	.002	3	8
LUNG_NSCLC_LUSC	KLF6 →	+2.434	+0.283	<.001	<.001	3	7
BLOOD_Leukemia	MAP4K4 →	+0.916	+0.134	.004	.002	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140058 vs ROCK1 — STOMACH

Explore this scatter interactively →