Neuron projection arborization

Across TCGA cell cohorts, RNA activity of the Neuron projection arborization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGF2BP1, CCL28, and BTBD9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection arborization activity versus IGF2BP1 in LUNG_SCLC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IGF2BP1 →	+3.116	+1.202	<.001	.002	3	8
SKIN	CCL28 →	-1.074	-1.317	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	BTBD9 →	-1.083	-1.574	.007	<.001	3	4
BREAST	CPE →	-4.486	-1.570	<.001	.003	3	4
BREAST	CARD14 →	-1.777	-1.182	<.001	.001	3	4
OVARY	DUSP8 →	-1.470	-1.530	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140058 vs IGF2BP1 — LUNG_SCLC

Explore this scatter interactively →