Mitochondrial gene expression

Across TCGA patient cohorts, RNA activity of the Mitochondrial gene expression pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB8B, MT-CO2, and VGLL3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial gene expression activity versus RAB8B in COAD (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAB8B →	-0.596	-0.243	<.001	<.001	3	8
LSCC	MT-CO2 →	+0.709	+0.412	<.001	<.001	3	8
OV	VGLL3 →	-0.835	-0.259	.006	.001	3	8
OV	RASGRF2 →	-0.780	-0.247	.002	.001	3	8
OV	ZEB2 →	-0.803	-0.244	.002	.001	3	8
OV	CSGALNACT2 →	-0.654	-0.222	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140053 vs RAB8B — COAD

Explore this scatter interactively →