Mitochondrial gene expression

Across TCGA cell cohorts, RNA activity of the Mitochondrial gene expression pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMAIP1, SLC5A6, and SAMD9L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PMAIP1 grouped by Mitochondrial gene expression-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PMAIP1 →	-1.205	-0.304	.001	.001	3	5
SOFT_TISSUE	SLC5A6 →	+0.934	+0.422	.002	.002	3	5
SOFT_TISSUE	SAMD9L →	-1.458	-0.662	.001	<.001	3	4
BREAST	TOB1 →	+1.620	+0.317	.001	<.001	3	4
SOFT_TISSUE	CAPG →	-5.238	-0.546	<.001	.006	3	4
URINARY_TRACT	ZNF697 →	+0.996	+0.439	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PMAIP1 by Mitochondrial gene expression activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →