Lipid droplet formation

Across TCGA patient cohorts, RNA activity of the Lipid droplet formation pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC37A17P, FAM199X, and VPS13C, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet formation activity versus LRRC37A17P in UCS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	LRRC37A17P →	+1.208	+0.069	<.001	<.001	3	31
UCS	FAM199X →	+0.932	+0.074	<.001	<.001	3	30
UCS	VPS13C →	+1.173	+0.072	<.001	<.001	3	30
CHOL	FAM13B →	+1.053	+0.089	<.001	<.001	3	30
DLBC	RAPGEF2 →	+1.170	+0.045	<.001	<.001	3	29
DLBC	ASH1L →	+1.370	+0.065	<.001	.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140042 vs LRRC37A17P — UCS

Explore this scatter interactively →