Lipid droplet formation

Across TCGA pan-cancer cohorts, RNA activity of the Lipid droplet formation pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 13 member genes.

The strongest signal is observed in thyroid carcinoma (THCA), where higher Lipid droplet formation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and ACC, show the opposite pattern, with higher activity associated with better survival.

THCA, UVM, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	II,III,IV	0.294	1.000	<.001	72	view →
UVM	DFS	Tertile	III,IV	0.303	0.755	.002	59	view →
KIRC	DFS	Median	All	0.863	0.728	.002	37	view →
CESC	DFS	Quartile	All	0.595	0.822	<.001	24	view →
ESCA	OS	Median	IV	0.135	0.568	.031	24	view →
ACC	OS	Quartile	II,III,IV	0.848	0.170	.005	23	view →
PRAD	DFS	Median	All	0.960	0.911	.010	18	view →
LUSC	OS	Median	All	0.321	0.455	.020	15	view →
READ	DFS	Tertile	IV	0.222	0.715	<.001	15	view →
SKCM	DFS	Median	IV	0.198	0.604	.003	15	view →
LAML	DFS	Quartile	All	0.614	0.395	.022	12	view →
SCLC	DFS	Quartile	All	0.261	0.810	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0140042–THCA (OS)

Open the THCA breakdown →