Lipid droplet formation

Across TCGA patient cohorts, RNA activity of the Lipid droplet formation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PATL1, SPR, and LDHD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet formation activity versus PATL1 in BRCA (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PATL1 →	-0.263	-0.039	<.001	<.001	3	5
UCEC	SPR →	+0.371	+0.042	<.001	.004	3	5
PDAC	LDHD →	+0.254	+0.024	.007	.008	3	5
LUAD	ITFG1 →	+0.304	+0.061	<.001	<.001	3	5
BRCA	NRDC →	-0.272	-0.033	<.001	.006	3	5
LUAD	ATP9A →	+0.466	+0.061	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140042 vs PATL1 — BRCA

Explore this scatter interactively →