Lipid droplet formation

Across TCGA patient cohorts, RNA activity of the Lipid droplet formation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASC15, RPL7, and CEP152, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet formation activity versus CASC15 in OV (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CASC15 →	-0.397	-0.256	<.001	.002	3	5
LUAD	RPL7 →	-0.376	-0.321	<.001	.003	3	4
UCEC	CEP152 →	-0.544	-0.695	<.001	<.001	3	4
GBM	MDFI →	-0.951	-0.279	.002	.006	3	4
GBM	CHTF18 →	-0.483	-0.260	<.001	.001	3	4
LSCC	MTHFD1L →	-0.272	-0.330	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140042 vs CASC15 — OV

Explore this scatter interactively →