Lipid droplet formation

Across TCGA cell cohorts, RNA activity of the Lipid droplet formation pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FST, TAS2R14, and CYP4F22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FST grouped by Lipid droplet formation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FST →	+0.240	+0.437	.007	.003	3	3
LARGE_INTESTINE	TAS2R14 →	+0.145	+0.296	.001	.005	3	3
CNS	CYP4F22 →	+0.190	+0.524	.007	.008	3	3
BREAST	RPS12 →	-0.310	-0.327	.004	.004	2	4
PANCREAS	CPQ →	-0.288	-0.453	.001	<.001	3	3
LUNG_SCLC	HES1 →	-0.202	-0.779	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FST by Lipid droplet formation activity — LIVER

Explore this box plot interactively →