Lipid droplet formation

Across TCGA cell cohorts, RNA activity of the Lipid droplet formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEX3D, SENP1, and PDCD10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet formation activity versus MEX3D in LUNG_SCLC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MEX3D →	-0.779	-0.438	.009	.002	2	5
BONE	SENP1 →	-1.080	-0.278	.006	.004	3	4
PANCREAS	PDCD10 →	-0.427	-0.475	.002	.005	3	3
BLOOD_Lymphoma	HLX →	+2.851	+0.830	.007	.004	3	3
STOMACH	YTHDF3 →	-0.889	-0.788	.004	.006	3	3
PANCREAS	MTAP →	-4.400	-0.383	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140042 vs MEX3D — LUNG_SCLC

Explore this scatter interactively →