L-aspartate import across plasma membrane

Across TCGA cell cohorts, RNA activity of the L-aspartate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL2, SERPINB7, and PIGG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-aspartate import across plasma membrane activity versus KLHL2 in BONE (Pearson r = -0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	KLHL2 →	-1.383	-0.348	<.001	.003	3	4
OESOPHAGUS	SERPINB7 →	+1.272	+0.165	.009	.005	2	4
OVARY	PIGG →	-1.130	-0.134	.007	.007	3	3
URINARY_TRACT	C19orf54 →	-1.626	-0.314	.003	.003	3	3
SKIN	APMAP →	+0.676	+0.285	.002	.009	3	3
SKIN	PCYOX1 →	+0.769	+0.392	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140009 vs KLHL2 — BONE

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