Mucociliary clearance

pathway activity — cross-omics
GO:0120197Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mucociliary clearance pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT122, SPA17, and UBXN10_S87, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECIFT122 →+0.438+0.278<.001<.00137
LSCCSPA17 →+1.010+0.202<.001<.00136
LSCCUBXN10_S87 →+0.900+0.141<.001<.00136
UCECWDR19 →+0.466+0.276<.001<.00136
LSCCCAPS →+0.904+0.154<.001<.00136
UCECCETN2_S20 →+0.440+0.241<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration