Mucociliary clearance

pathway activity — cross-omics
GO:0120197Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mucociliary clearance pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR1272, RNU6-1247P, and CDC25B, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADMIR1272 →-1.143-0.326<.001.00132
LUADRNU6-1247P →-1.172-0.299<.001.00532
GBMCDC25B →-0.600-0.157.001.00231
GBMNPRL3 →-0.554-0.161.004<.00131
GBMPPP1R13L →-0.723-0.162.003.00531
GBMCALCOCO1 →-0.515-0.229.005.00131
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration