Negative regulation of protein localization to chromatin

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization to chromatin pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP88, STAT5B, and CPEB4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUP88 grouped by Negative regulation of protein localization to chromatin-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NUP88 →	-0.566	-0.128	.004	.002	2	8
LUNG_SCLC	STAT5B →	+0.790	+0.178	.006	<.001	3	5
OVARY	CPEB4 →	+1.325	+0.170	<.001	.001	3	5
OVARY	C11orf52 →	+1.535	+0.147	.003	.004	3	5
OVARY	RECQL →	-0.865	-0.123	.004	.003	3	5
BLOOD_Leukemia	PSEN1 →	+0.808	+0.219	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUP88 by Negative regulation of protein localization to chromatin activity — OVARY

Explore this box plot interactively →