Negative regulation of cold-induced thermogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of cold-induced thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT2A, FMO5, and PLK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cold-induced thermogenesis activity versus MT2A in LIVER (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MT2A →	-4.058	-0.497	.002	.002	3	4
LIVER	FMO5 →	+1.918	+0.547	.001	.001	3	4
LIVER	PLK3 →	-0.997	-0.537	.001	.006	3	4
LIVER	RAC2 →	-4.926	-0.491	<.001	.007	2	4
BLOOD_Leukemia	TRIM21 →	-0.885	-0.193	<.001	.005	2	4
BREAST	TMSB15A →	-1.836	-0.215	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120163 vs MT2A — LIVER

Explore this scatter interactively →