Positive regulation of cold-induced thermogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of cold-induced thermogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ELMO1, SYNC, and SYNPO2_S363, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cold-induced thermogenesis activity versus ELMO1 in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ELMO1 →	+0.359	+0.043	<.001	<.001	3	6
GBM	SYNC →	+0.431	+0.037	<.001	<.001	3	6
PDAC	SYNPO2_S363 →	+1.029	+0.041	<.001	<.001	3	6
BRCA	TIMM23 →	-0.543	-0.026	<.001	.001	3	6
LSCC	TNS2_S102 →	+0.626	+0.034	<.001	<.001	3	6
BRCA	YTHDC1_S308 →	-0.763	-0.026	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120162 vs ELMO1 — GBM

Explore this scatter interactively →