Negative regulation of plasma membrane bounded cell projection assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of plasma membrane bounded cell projection assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN3, FAM83D, and LMNB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of plasma membrane bounded cell projection assembly activity versus CDKN3 in LUAD (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDKN3 →	-1.055	-0.214	<.001	<.001	3	6
HNSC	FAM83D →	-1.137	-0.169	<.001	<.001	3	6
LSCC	LMNB1 →	-0.824	-0.188	<.001	<.001	3	6
HNSC	KIF18A →	-0.895	-0.152	.001	.001	3	6
LSCC	DSCC1 →	-0.968	-0.215	<.001	<.001	3	6
HNSC	TDG →	-0.561	-0.139	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120033 vs CDKN3 — LUAD

Explore this scatter interactively →