Intermembrane lipid transfer

Across TCGA cell cohorts, RNA activity of the Intermembrane lipid transfer pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ESYT1, VAT1, and ATIC, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermembrane lipid transfer activity versus ESYT1 in BONE (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ESYT1 →	+1.083	+0.938	<.001	<.001	3	10
BLOOD_Lymphoma	VAT1 →	+1.881	+1.118	<.001	<.001	3	9
OVARY	ATIC →	-1.399	-0.242	<.001	.009	3	8
KIDNEY	CIAPIN1 →	-0.830	-0.155	.003	.008	3	8
CNS	TRMT112 →	-1.176	-0.612	<.001	.006	3	7
OVARY	BTF3 →	-1.826	-0.345	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120009 vs ESYT1 — BONE

Explore this scatter interactively →