Positive regulation of animal organ morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of animal organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFTN2, ZNF423, and FGF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of animal organ morphogenesis activity versus RFTN2 in LUAD (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFTN2 →	+0.300	+0.372	.008	.002	3	5
CCRCC	ZNF423 →	+0.420	+0.729	.001	.001	3	5
CCRCC	FGF1 →	+0.969	+0.862	<.001	.001	3	5
UCEC	CEP55 →	-0.689	-0.674	.001	.001	3	5
CCRCC	NCAPG2 →	-0.290	-0.895	.002	<.001	3	5
UCEC	SKA3 →	-0.741	-0.675	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110110 vs RFTN2 — LUAD

Explore this scatter interactively →