mRNA alternative polyadenylation

Across TCGA patient cohorts, RNA activity of the mRNA alternative polyadenylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADNP, RBM12B, and RPL7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA alternative polyadenylation activity versus ADNP in HNSC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADNP →	+0.220	+0.080	.004	.004	3	6
HNSC	RBM12B →	+0.254	+0.089	<.001	.002	3	6
UCEC	RPL7 →	-0.367	-0.043	<.001	.006	3	5
HNSC	LIMA1_S609 →	-0.590	-0.056	<.001	<.001	3	5
UCEC	RPRD1B →	+0.393	+0.080	<.001	<.001	3	5
LUAD	ITPRID2_S767 →	-0.519	-0.037	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110104 vs ADNP — HNSC

Explore this scatter interactively →