mRNA alternative polyadenylation

Across TCGA cell cohorts, RNA activity of the mRNA alternative polyadenylation pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPSF7, NUDT21, and SF3B2, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA alternative polyadenylation activity versus CPSF7 in LUNG_NSCLC_LUSC (Pearson r = 0.92).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CPSF7 →	+1.084	+0.302	<.001	<.001	3	20
LUNG_NSCLC_LUSC	NUDT21 →	+0.870	+0.251	<.001	.002	3	18
UPPER_AERODIGESTIVE_TRACT	SF3B2 →	+0.698	+0.326	<.001	<.001	3	13
KIDNEY	CDC5L →	+0.669	+0.237	<.001	<.001	3	13
CNS	PRPF19 →	+0.535	+0.135	<.001	.001	2	14
CNS	BCAS2 →	+0.662	+0.183	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110104 vs CPSF7 — LUNG_NSCLC_LUSC

Explore this scatter interactively →