Cellular response to aldehyde

Across TCGA patient cohorts, RNA activity of the Cellular response to aldehyde pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B10, PABPC1L, and ASXL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to aldehyde activity versus AKR1B10 in LUAD (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKR1B10 →	+2.017	+0.102	<.001	<.001	3	5
COAD	PABPC1L →	-0.843	-0.148	.003	<.001	3	4
COAD	ASXL1 →	-0.471	-0.116	.004	.003	3	4
UCEC	SS18L1 →	-0.296	-0.084	.003	.001	3	4
LUAD	ALDH3A1 →	+1.835	+0.146	.001	<.001	3	4
LSCC	TEF →	+0.584	+0.139	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110096 vs AKR1B10 — LUAD

Explore this scatter interactively →