Regulation of G2/MI transition of meiotic cell cycle

Across TCGA patient cohorts, RNA activity of the Regulation of G2/MI transition of meiotic cell cycle pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RFC4, and RPL12_S38, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of G2/MI transition of meiotic cell cycle activity versus RFC2 in LSCC (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC2 →	+0.500	+0.125	<.001	<.001	3	10
LSCC	RFC4 →	+0.547	+0.115	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.186	+0.119	<.001	<.001	3	10
BRCA	RRM1 →	+0.581	+0.098	<.001	<.001	3	10
UCEC	RRM2 →	+0.929	+0.242	<.001	.002	3	10
LUAD	ATAD2_S342 →	+1.318	+0.110	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110030 vs RFC2 — LSCC

Explore this scatter interactively →