Regulation of G2/MI transition of meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Regulation of G2/MI transition of meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB1, CDC25A, and MAD2L1, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of G2/MI transition of meiotic cell cycle activity versus LMNB1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	LMNB1 →	+1.313	+0.091	<.001	<.001	3	19
BONE	CDC25A →	+1.588	+0.189	.001	<.001	3	18
SOFT_TISSUE	MAD2L1 →	+1.312	+0.115	<.001	<.001	3	18
LUNG_NSCLC_LUSC	ORC1 →	+1.379	+0.103	<.001	<.001	3	17
SOFT_TISSUE	RAD54L →	+1.292	+0.123	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	GINS1 →	+1.810	+0.151	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110030 vs LMNB1 — UPPER_AERODIGESTIVE_TRACT

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