DNA strand resection involved in replication fork processing

Across TCGA patient cohorts, RNA activity of the DNA strand resection involved in replication fork processing pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1106, MCM2, and MCM3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA strand resection involved in replication fork processing activity versus TOP2A_S1106 in LUAD (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1106 →	+1.368	+0.134	<.001	<.001	3	10
LUAD	MCM2 →	+0.838	+0.137	<.001	<.001	3	10
LUAD	MCM3 →	+0.867	+0.134	<.001	<.001	3	10
LUAD	MCM4 →	+0.888	+0.137	<.001	<.001	3	10
UCEC	RFC1_T506 →	+1.328	+0.132	<.001	<.001	3	10
LUAD	MCM2_S139 →	+1.057	+0.127	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110025 vs TOP2A_S1106 — LUAD

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