Basolateral protein secretion

Across TCGA patient cohorts, RNA activity of the Basolateral protein secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP1G1, ATP6V0A1, and ERBB3_S686, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Basolateral protein secretion activity versus AP1G1 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AP1G1 →	+0.187	+0.052	.004	.001	3	5
GBM	ATP6V0A1 →	+0.307	+0.057	.003	.001	3	4
LSCC	ERBB3_S686 →	+0.442	+0.042	.008	.004	3	4
LSCC	NECTIN4_S426 →	+1.127	+0.062	<.001	<.001	3	4
HNSC	TRAF1 →	-0.565	-0.168	<.001	<.001	3	4
HNSC	BOD1L1 →	-0.153	-0.096	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110010 vs AP1G1 — BRCA

Explore this scatter interactively →