Purine ribonucleotide salvage

Across TCGA cell cohorts, RNA activity of the Purine ribonucleotide salvage pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD13B, SSBP4, and MYC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleotide salvage activity versus ANKRD13B in STOMACH (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ANKRD13B →	+1.507	+0.767	.003	.006	3	7
LUNG_SCLC	SSBP4 →	+1.091	+0.279	<.001	<.001	3	6
OVARY	MYC →	+1.553	+1.231	<.001	.004	3	6
STOMACH	CISD3 →	+1.108	+1.069	.007	.008	2	6
BLOOD_Lymphoma	ALDH1B1 →	+0.836	+0.240	.001	.002	3	5
URINARY_TRACT	TMEM201 →	+0.469	+1.722	.003	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106380 vs ANKRD13B — STOMACH

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