tRNA surveillance

Across TCGA patient cohorts, RNA activity of the tRNA surveillance pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMU1, SUPT16H, and UHRF2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA surveillance activity versus SMU1 in LUAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMU1 →	+0.154	+0.052	<.001	<.001	3	7
OV	SUPT16H →	+0.297	+0.039	.006	.003	3	7
BRCA	UHRF2 →	+0.308	+0.043	.001	<.001	3	7
LUAD	ADAR →	+0.242	+0.042	<.001	.001	3	7
HNSC	GRHPR →	+0.427	+0.093	<.001	<.001	3	7
OV	SPIN1 →	+0.480	+0.050	<.001	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106354 vs SMU1 — LUAD

Explore this scatter interactively →