Aminoacyl-tRNA metabolism involved in translational fidelity

Across TCGA cell cohorts, RNA activity of the Aminoacyl-tRNA metabolism involved in translational fidelity pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMACHC, GDPD1, and LARP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminoacyl-tRNA metabolism involved in translational fidelity activity versus MMACHC in LARGE_INTESTINE (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMACHC →	+0.963	+0.271	.002	.008	3	5
LARGE_INTESTINE	GDPD1 →	+1.405	+0.303	<.001	.001	3	5
BREAST	LARP1 →	+0.476	+0.151	.003	.004	3	4
BLOOD_Myeloma	MRPS25 →	+0.626	+0.321	.005	.004	3	4
LARGE_INTESTINE	RGS16 →	+1.918	+0.324	<.001	<.001	3	4
LARGE_INTESTINE	OXSM →	+0.675	+0.222	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106074 vs MMACHC — LARGE_INTESTINE

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