Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP210, DENND2C, and TAPBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus NUP210 in COAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NUP210 →	-0.778	-0.610	.005	.006	3	5
BRCA	DENND2C →	+0.464	+0.195	<.001	.003	3	4
CCRCC	TAPBP →	-0.478	-0.367	.001	.008	3	4
LUAD	DNAL4 →	+0.265	+0.206	.005	.002	3	3
LUAD	TTLL1 →	+0.239	+0.201	.005	.003	3	3
LUAD	CGRRF1 →	+0.333	+0.279	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106072 vs NUP210 — COAD

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