Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALCOCO2, FBXO8, and HOMER1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALCOCO2 grouped by Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CALCOCO2 →	-1.206	-1.038	.002	.003	3	4
BLOOD_Leukemia	FBXO8 →	-0.619	-0.988	.001	.003	3	4
OVARY	HOMER1 →	-0.810	-0.812	.004	.004	3	4
OVARY	GPHN →	-1.070	-1.344	.008	.001	2	5
SKIN	DYRK1B →	-1.137	-1.080	.005	<.001	3	4
SKIN	RAB32 →	+0.836	+0.677	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALCOCO2 by Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →