Positive regulation of calcineurin-mediated signaling

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcineurin-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, INCENP, and HEXA-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcineurin-mediated signaling activity versus TTK in LUAD (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TTK →	-0.817	-0.134	<.001	<.001	3	4
UCEC	INCENP →	-0.672	-0.212	<.001	<.001	3	4
PDAC	HEXA-AS1 →	+0.232	+0.177	.006	.006	3	4
LUAD	MIR148B →	+0.524	+0.118	.004	.003	3	4
PDAC	MCM7 →	-0.371	-0.146	.009	.009	3	4
LUAD	VRK1 →	-0.509	-0.125	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106058 vs TTK — LUAD

Explore this scatter interactively →