Negative regulation of calcineurin-mediated signaling

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcineurin-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENTPD4, LHB, and RELB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENTPD4 grouped by Negative regulation of calcineurin-mediated signaling-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ENTPD4 →	-1.286	-1.246	.002	<.001	3	4
CNS	LHB →	-1.069	-0.922	<.001	<.001	3	3
OESOPHAGUS	RELB →	-1.117	-1.061	<.001	<.001	3	3
CNS	PCNX2 →	-0.803	-0.974	.006	.002	3	3
OESOPHAGUS	ZNF23 →	-0.796	-1.141	<.001	<.001	3	3
CNS	CD47 →	-0.658	-0.668	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENTPD4 by Negative regulation of calcineurin-mediated signaling activity — OESOPHAGUS

Explore this box plot interactively →