Regulation of calcineurin-mediated signaling

Across TCGA patient cohorts, RNA activity of the Regulation of calcineurin-mediated signaling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170, DOCK2, and DPYD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcineurin-mediated signaling activity versus CEP170 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CEP170 →	+0.310	+0.047	<.001	<.001	3	7
BRCA	DOCK2 →	+0.395	+0.029	<.001	<.001	3	7
GBM	DPYD →	+0.909	+0.053	<.001	<.001	3	7
GBM	LCP1 →	+0.616	+0.042	<.001	<.001	3	7
GBM	MYO1F →	+0.446	+0.046	<.001	<.001	3	7
GBM	ARHGAP30 →	+0.504	+0.040	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106056 vs CEP170 — BRCA

Explore this scatter interactively →